21-1 Front

Exploration of Some Marine Flora and Fuana



Dr. Poonam gupta
Assistant Professor
M.M.H.College, Ghaziabad

Dr. Ajet Saxena
Former Scientist
Jubilant Lifesciences, Noida

Pages 108

Year 2018

ISBN: 978-93-87922-21-1

Category: Tag:

Product Description


The Ocean, which is called the ‘mother of origin of life’, is also the source of structurally unique natural products that are mainly accumulated in living organisms. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immuno-deficiency syndrome (AIDS), arthritis, etc., while other compounds have been developed as analgesics or to treat inflammation, etc. The lifesaving drugs are mainly found abundantly in microorganisms, algae and invertebrates, while they are scarce in vertebrates. Modern technologies have opened vast areas of research for the extraction of biomedical compounds from oceans and seas.
Marine natural products are small- to medium- molecular weight compounds produced by marine plants, invertebrates and microbes that have stimulated interdisciplinary studies by chemists and biologists. From marine toxins that impact public health concerns to the search for new drugs from the sea, the study of biologically active marine natural products has profoundly influenced the course of discovery in fields ranging from pharmacology to cancer medicine. Extraordinary chemical diversity is the hallmark of marine natural products structures. Marine natural products, such as the ion-channel modulators gamma-conotoxins, ciguatoxins and tetrodotoxin have found extensive use in neuropharmacology and their properties continue to be the subject of new discovery. Novel classes of marine alkaloids have been found to intervene in key receptors of cell-cycle, enzymes or other targets and lead to insights into new therapeutics. Studies in biodiversity and chemical ecology reveal roles of natural products and organizing principles; not only at the species level, but also within the context of marine environmental dynamics that shape communities ranging from tropical reefs to the Antarctic benthos.

Application of sophisticated techniques of isolation such as preparative HPLC, droplet counter current chromatography and those of structure elucidation viz. FAB-MS, HRMS, 2D-NMR spectroscopy (1H-1H COSY, HMQC, HMBC, HETCOR and NOESY etc.) and X-ray crystallography have contributed immensely to the isolation and characterization of novel molecules from marine sources, which generally afford these compounds in low yields. The Indian region of the ocean (the Bay of Bengal, Andaman and Nicobar Islands, Gulf of Mannar, Lakshadeep Island and Arabian Sea) is the repository of a biodiversity and is a rich source of flora and fauna which have not been explored yet. The marine ecosystem is being investigated to find new bioactive molecules at many institutions of India.
The work reported in the present text pertains to the detailed chemical investigation of three marine flora and fauna. The work embodied here is divided into four chapters.
Chapter-1 presents general introduction of marine natural products.
Chapter-2 deals with some of chemical constituents from the mangrove Xylocarpus molluccensis, their isolation and characterization methods.
Chapter-3 deals with the isolation and characterization of two new ceramides along with a pyrone and some other metabolites from the sponge Cinachyra cavernosa.
Chapter-4 presents the work carried out with the red alga Halymenia porphyroides.